| External factors: | HIV infection |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | HIV |
| Experiment: | Confocal microscopy |
| Description: | To determine telomeric DDR in HIV-infected SupT1 and primary CD4 T cells, we compared the number of TIFs by examining the co-localization of 53BP1 and TRF1 using confocal microscopy. |
| Target gene: | ATM |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | ATM |
| Target gene experiment: | Western blot |
| Target gene description: | Western blot analysis of p24, ATM, CHK2, AKT, PARP-1, and γH2AX expressions in SupT1 cells at day 6 of HIV infection. |
| Regulatory pathway: | PI3K-ATM |
| R-EF-Pathway: | Downregulation |
| Pathway experiment: | Western blot |
| Pathway description: | Western blot analysis of p24, ATM, CHK2, AKT, PARP-1, and γH2AX expressions in SupT1 cells at day 6 of HIV infection. B) Western blot analysis of p24, ATM, CHK2, AKT, PARP-1, andγH2AX expressions in primary CD4 cells at day 5 of HIV infection. |
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