| External factors: | Glucagon‐like peptide 1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | Pre‐incubation with GLP‐1 significantly reduced 5FU‐elicited senescence of EA.hy926 cells. This effect occurred through GLP‐1 receptor, as it was attenuated by the GLP‐1 receptor antagonist, E9. GLP‐1 prevented endothelial cells senescence initiated by sera from patients taking capecitabine. |
| Target gene: | PKA//ERK1/2//PI3K//NOS |
| R-EF-Target gene: | Downregulation//Downregulation//Downregulation//Downregulation |
| Official symbol(s): | PRKACA//ERK1/2//PIK3CD//NOS1 |
| Target gene experiment: | Western blot//Densitometry analysis |
| Target gene description: | GLP‐1 prevented endothelial cells senescence initiated by sera from patients taking capecitabine, with this effect being eliminated by antagonism of GLP‐1 receptors or inhibition of PKA, ERK1/2, PI3K and NOS. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: