| External factors: | 78c |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | Immunostaining |
| Description: | Accompanying these physiological improvements observed in aged mice, 78c treatment reversed several morphological features of aging in skeletal muscle .Strikingly, the number of centrally located nuclei, presence of inflammatory cell infiltrates, and number of necrotic myofibers decreased by more than 70% in aged mice treated with 78c. |
| Regulatory pathway: | AMPK//mTOR-p70S6K//ERK |
| R-EF-Pathway: | Activation//Downregulation//Downregulation |
| Official symbol(s): | AMPK//MTOR//ERK |
| Pathway experiment: | Western blot |
| Pathway description: | One-year-old 78c-treated mice exhibited significant activation of the pro-longevity AMPK pathway in spleen and skeletal muscle . Changes induced by 78c in the AMPK pathway were further confirmed in A549 cells and mouse bone marrow-derived macrophages, which express endogenous CD38 .On the other hand, 78c decreased the activation of the mTOR-p70S6K and ERK pathways in the spleen and skeletal muscle of 1-year-old mice. |
Annotation: