Aging Overview

External factors

External factors: UDCA
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Colorectal cancer
Experimental category: HL
Tissue type: --
Cell name: HCT116
PMID: 17019713
Experiment: Cell morphological analysis//SA-β-gal activity assay
Description: The experiment to assess morphological changes associated with UDCA treatment led to the observation that UDCA induces flat and spread out morphology similar to that described for the senescent cells.The staining for senescence marker βOur results show a significant suppression of telomerase activity by UDCA-galac-tosidase revealed intense β-galactosidase staining pattern in UDCA treated HCT116 (UDCA_P3) cells, when compared with untreated HCT116 cells, suggesting that UDCA induces senescence in HCT116 cells.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.