| External factors: | Formaldehyde |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//EdU assay//Western blot |
| Description: | We found that the ability of FA-treated IMR90 cells to enter into stable replication arrest, and senescence was completely dependent on p53. |
| Target gene: | P53 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | P53 |
| Target gene experiment: | Western blot |
| Target gene description: | Stress-responsive phosphorylation of p53 at Ser15 was already detectable after a 30-min-long FA treatment and increased further at longer 1–3 h exposures . Ser15 phosphorylation and p53 protein levels continued to increase for several hours after FA removal. At 6 h post-exposure, a strong phosphorylation at Ser15 was observed with as low as 50 μM FA, which is within its physiological concentration range in human serum.22. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: