Aging Overview

External factors

External factors: 6-diazo-5-oxo-L-norleucine
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: HUVEC
PMID: 18317946
Experiment: SA-β-gal activity assay
Description: Exposure of both, early-passage (20 PDL) and late-passage (52 PDL) HUVEC cultures to DON strongly inhibited cell proliferation. Furthermore, exposure of early-passage HUVEC to the glutaminase inhibitor induced phenotypic alterations typically of premature senescence within two passages,The percentage of SA-β gal positive cells increased from 7.4 ± 1% to 25 ± 3% in young HUVEC exposed to 10 lM DON, and reached 66.0 ± 4% when 40 lM DON was used.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.