| External factors: | pIFN- α |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Melanoma |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis |
| Description: | We observed that upon exposure to pIFN-α,cells became enlarged, flattened, irregularly shaped and significantly more cells expressed SA β-gal+, suggesting a senescent phenotype as compared with untreated cell cultures. |
| Regulatory pathway: | IRF-1 |
| R-EF-Pathway: | -- |
| Official symbol(s): | IRF1 |
| Pathway experiment: | Western blot |
| Pathway description: | Interestingly, treatment with 0.25 or 0.5 mg/ml pIFN-a induced the same level of IRF-1. |
Annotation: