Aging Overview

External factors

External factors: L2-Cmu
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: Heart
Cell name: --
PMID: 29921922
Experiment: PI stainingng//ELISA
Description: L2-Cmu treatment in females did not adversely affect cardiac function, but instead restored diastolic function to more youthful levels.Importantly, late-life L2-Cmu treatment improved mean lifespan (P=0.023) and increased median lifespan by 9% (P=0.03) in females. Aging in females was characterized by a significant rise in IL-1β, IL-4, IL-5, IL-6, IL-10,IL-12(p40), IL-12(p70), IL-17, CXCL-10, CXCL-1, MIP-1α, MIP-2, and TNFα, but several of these cytokines and chemokines were restored to a more youthful level with mAb treatment. In contrast, only G-CSF, IL-6,and RANTES were elevated in old male plasma, but mAb treatment led to a marked increase in the majority of these markers.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.