| External factors: | Glucocorticoid |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | ELISA//qRT-PCR//Knockdown |
| Description: | The proliferation rates of MSCs 4 weeks after being treated to block endogenous GCs were significantly higher than controls .Treatment with RU486 or GR siRNA significantly up-regulated the expression of telomerase mRNA . The telomere lengths of MSCs treated with RU486 were significantly longer than those in controls . The MSCs treated with GR siRNA also had relatively longer telomeres than those in controls, but the differences are marginally significant (p=0.0625). In addition, total SOD activity, which is a key antioxidant, was 30–40% higher in MSCs that had been treated with RU486 or GR siRNA than in controls and these differences were statistically significant. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: