| External factors: | Vemurafenib |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Melanoma |
| Experiment: | SA-β-gal activity assay//Flow cytometry//Cell morphological analysis |
| Description: | In M14 and Malme 3M cells, an increased proportion of the surviving cells was found in G0/G1 after 7 days of Vemurafenib treatment.All cells displaying an enlarged phenotype showed increased senescence-associated β-galactosidase (SA-β-Gal) activity, supporting the notion that Vemurafenibcan induce senescence features in BRAF-dependent melanoma cell lines. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: