| External factors: | TMAO |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | R1-C mice showed a few SA-beta-GAL-positive cells,whereas the R1-T and P8-C groups had more cells showing prominent SA-beta-GAL staining. As expected, the P8-T group had the most cells showing robust SA-beta-GAL staining among all groups. |
| Regulatory pathway: | mTOR |
| R-EF-Pathway: | Downregulation |
| Official symbol(s): | MTOR |
| Pathway experiment: | Western blot//qRT-PCR |
| Pathway description: | The phosphorylation levels of mTOR, p70s6k and 4EBP2 were significantly decreased in P8-C compared with R1-C.These proteins were decreased significantly in the TMAO groups compared to the control groups, especially in P8-T. |
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