Aging Overview

External factors

External factors: H2O2
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: ADSC
PMID: 25654692
Experiment: Immunostaining//SA-β-gal activity assay
Description: We found that the number of Ki-67 positive cells was dramatically decreased after H2O2 induction, indicating a significant decrease in the proliferation rate;The cells were treated with 100 μM H2O2 for 2 h and SA-β-gal staining was performed. It was noted that, following H2O2-induced senescence, the percentage of SA-β-gal positive cells increased significantly.


Regulatory relationship

Target gene: P53//P21
R-EF-Target gene: Upregulation//Upregulation
Official symbol(s): P53//P21
Target gene experiment: Semi-qPCR//qPCR
Target gene description: Cell cycle marker genes such as p21 and p53 were initially upregulated post H2O2 treatment.

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.