| External factors: | Tamoxifen |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Breast cancer |
| Experiment: | SA-β-gal activity assay |
| Description: | SA-β-gal staining in both MCF-7 and HCT116 cells increased with tamoxifen treatment. |
| Target gene: | CK2 |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | CSNK2A1 |
| Target gene experiment: | Western blot |
| Target gene description: | Endogenous CK2 activity was reduced in MCF-7 and HCT116 cells treated with tamoxifen. |
| Regulatory pathway: | p53-p21 |
| R-EF-Pathway: | Upregulation |
| Official symbol(s): | TP53-CDKN1A |
| Pathway experiment: | Western blot |
| Pathway description: | Immunoblotting showed that the protein levels of p53 and p21Cip1/WAF1 were up-regulated in tamoxifen-treated cells. |
Annotation: