Aging Overview

External factors

External factors: 4-hydroxytamoxifen
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Acute leukemia
Experimental category: L
Tissue type: --
Cell name: ALT
PMID: 19468068
Experiment: SA-β-gal activity assay//BrdU assay//Western blot
Description: After 4 d of 4OHT treatment, many of the cells had undergone the characteristic morphological changes of senescence and stained positive for senescence-associated (SA) β-galactosidase (SA-β-gal) activity . Most of the cells that were morphologically senescent contained APBs, Triple staining for BrdU, p21, and TRF1 revealed that most of the APB-positive cells were p21 positive and BrdU negative .


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.