| External factors: | 4-hydroxytamoxifen |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Acute leukemia |
| Experiment: | SA-β-gal activity assay//BrdU assay//Western blot |
| Description: | After 4 d of 4OHT treatment, many of the cells had undergone the characteristic morphological changes of senescence and stained positive for senescence-associated (SA) β-galactosidase (SA-β-gal) activity . Most of the cells that were morphologically senescent contained APBs, Triple staining for BrdU, p21, and TRF1 revealed that most of the APB-positive cells were p21 positive and BrdU negative . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: