| External factors: | NAX014 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Breast cancer |
| Experiment: | SA-β-gal activity assay |
| Description: | NAX014 and, to a lesser extent, BBR administration increased the number of cells with a senescent-like phenotype in mammary tumor samples, as evidenced by the increased SA-β-gal staining. |
| Target gene: | P16 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | P16 |
| Target gene experiment: | qRT-PCR |
| Target gene description: | NAX014 induced a significant dose-dependent upregulation of p16INK4a mRNA level. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: