| External factors: | PD-0332991 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Esophageal cancer |
| Experiment: | SA-β-gal activity assay |
| Description: | Treatment with PD-0332991 drastically increased the activity of SA-β-gal, a marker for senescent cells in EC109 and EC9706 cells. |
| Target gene: | FOXM1 |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | FOXM1 |
| Target gene experiment: | Western blot//SA-β-gal activity assay |
| Target gene description: | Western blotting analysis revealed that the protein level of FOXM1 was decreased by PD-0332991 in a concentration-dependent manner. Importantly, compared with si-control transfection, knockdown of FOXM1 obviously potentiated the PD-0332991-induced cellular senescence, as indicated by a significant increase in the percentage of SA-β-gal positive cells. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: