| Description: |
We found that SA-β-Gal activity in rapamycin-treated HCAECs was clearly reduced with every schedule of rapamycin treatment,It was observed that the H2O2-treated HCAECs had a higher G2/M fraction than the control HCAECs (24.0 ± 1.8% vs. 12.2 ± 4.8%), wherein the rapamycin-treated HCAECs revealed a comparatively higher G2/M fraction than that of H2O2-treated HCAECs (I, 29.4 ± 1.8%; II, 28.1 ± 5.3%; III, 27.5 ± 3.7%; IV, 29.2 ± 4.7% vs. H2O2-treated, 24.0 ± 1.8%).The levels of these including IL-1α, IL-1β, IL-8, GROα, TNFα, MCP1, and GMCSF were significantly upregulated with SIPS. However, in rapamycin-treated HCAECs, all examined SASP factors were drastically reduced with every schedule of rapamycin treatment. |