| External factors: | OVX surgery |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Menopause |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | The ratio of arterial senescence,assessed by SA-β gal,was greater in OVX mice than in sham mice.Western blot analysis revealed that the arterial expression of SIRT1 protein and the ratio of p-eNOS to eNOS were lower in OVX mice than in sham mice and the expression of Ac-p53, p21, p16, and PAI-1 was higher in OVX mice than in sham mice . |
| Target gene: | SIRT1 |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | SIRT1 |
| Target gene experiment: | Western blot |
| Target gene description: | Western blot analysis revealed that the arterial expression of SIRT1 protein and the ratio of p-eNOS to eNOS were lower in OVX mice than in sham mice and the expression of Ac-p53, p21, p16, and PAI-1 was higher in OVX mice than in sham mice. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: