Aging Overview

External factors

External factors: JQ1
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Osteosarcoma
Experimental category: HL
Tissue type: --
Cell name: G-292,MG-63,MNNG/HOS,SJSA
PMID: 25307878
Experiment: SA-β-gal activity assay//Flow cytometry//PI staining
Description: JQ1 (7.5 μM, 24 hr) increased the percentage of G1 phase cells in G292, MNNG/HOS and SJSA cells, but not MG‐63 cells.a prominent increase in premature senescence of these cells was observed when tested in the same condition by senescence‐associated β‐galactosidase (SA‐β‐gal) staining. MG‐63 cells showed no increase in the number of cells undergoing senescence.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.