| External factors: | Carbamide peroxide |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Myeloma |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | In the myeloma cell KM-HM_(31), CP treated cell and increased levels of aging proteins P53 and P16, indicating the establishment of a successful aging model for further studies. |
| Target gene: | SIRT6 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | SIRT6 |
| Target gene experiment: | Western blot |
| Target gene description: | We further observed that in cell aging model, Sirtuin 6 level was apparently increased, indicating the possible role of Sirtuin 6 to CP-induced myeloma cell KM-HM_(31) aging. |
| Regulatory pathway: | Hippo |
| R-EF-Pathway: | Downregulation |
| Official symbol(s): | STK4 |
| Pathway experiment: | Western blot |
| Pathway description: | Also, the evident reduction of Hippo was found in myeloma cell aging model compared to normal control. |
Annotation: