| External factors: | MALAT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | In addition, the ratio of senescent cells was significantly lower following intervention with MALAT1 siRNA (52.1%) compared with the UVB irradiation group. |
| Target gene: | MMP1 |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | MMP1 |
| Target gene experiment: | ELISA |
| Target gene description: | The results demonstrated that MALAT1 siRNA suppressed MALAT1 expression and inhibited 60 mJ/cm2 UVB-induced MMP-1 secretion . |
| Regulatory pathway: | MAPK |
| R-EF-Pathway: | -- |
| Official symbol(s): | MAPK |
| Pathway experiment: | Western blot |
| Pathway description: | The results demonstrated that 60 mJ/cm2 UVB upregulated ERK, JNK and p38 phosphorylation levels, however MALAT1 siRNA inhibited UVB-induced ERK phosphorylation (P<0.01), with no significant influence on JNK and p38 phosphorylation levels. |
Annotation: