| External factors: | Hinokitiol |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Lung cancer |
| Experimental category: | HL |
| Tissue type: | Tumor tissue |
| Cell name: | A549,H1975,H1299,H3255,PC-9,PC-9-IR |
| PMID: | 25105411 |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | The effect of hinokitiol on cellular senescence was assessed through SA-β-Gal staining, and we found that hinokitiol treatment (5 μM, 72 h) induced cellular senescence in H1975 cells and, more significantly, in human lung stromal fibroblasts.This result indicated that hinokitiol induced the accumulation of cancer cells in the S phase of the cell cycle. Interestingly, this effect on cell cycle distribution was not significantly observed in human lung stromal fibroblasts treated with hinokitiol. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: