Aging Overview

External factors

External factors: Estrogen
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: Bone marrow,Bone
Cell name: MSC,Chondrocyte
PMID: 21469181
Experiment: Telomere length assay//Southern blot
Description: Telomere length declined over the entire observation period for all experimental groups to values ranging from 6.4 to 9.8 kbp,with increasing concentrations of E2 treatment, mean telomere shortening decreased(MSCs).Telomere length declined for all experimental groups to values ranging from 8.2 to 10.2 kbp. Telomere shortening correlated with cpd (P < 0.001). With increasing concentrations of E2 treatment, mean telomere shortening decreased(Human chondrocytes).


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.