| External factors: | Estrogen |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Werner syndrome |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | Estrogen was able to block the adriamycin-induced DcR2 and p16/INK4A, molecular markers of senescence. SA-β-Gal staining also showed a similar pattern so that estrogen was able to block the adriamycin-induced senescence . |
| Target gene: | WRN |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | WRN |
| Target gene experiment: | Western blot |
| Target gene description: | The transcript of WRN was induced by estrogen treatment in a time-dependent manner. In the same cell line, we could also observe the induction of WRN protein expression. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: