| External factors: | NS-398 |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | Flow cytometry |
| Description: | We demonstrated that the proportions of cells that progressed through the G0/G1into the S phase were increased by NS-398 compared with the controls. |
| Target gene: | COX-2//P53//PCNA//MMP1 |
| R-EF-Target gene: | Downregulation//Downregulation//--//Downregulation |
| Official symbol(s): | COX2//P53//PCNA//MMP1 |
| Target gene experiment: | Western blot |
| Target gene description: | Treatment with NS-398 during replicative senescence inhibited the senescence-associated increase in COX-2 protein expression completely in the replicative senescent fibroblasts.NS-398 inhibited the senescence-associated increase in p53 expression during replicative senescence almost completely.NS-398 inhibited the senescence-associated decrease in PCNA protein expression during the replicative senescence of dermal fibroblasts.Treatment with NS-398 during replicative senescence decreased the senescence-associated increase in MMP-1 expression. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: