| External factors: | High glucose |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Western blot//SAHF |
| Description: | The expressions of senescence-associated markers, including P16, P21, cell membrane DcR2, cytoplasmic SA-β-Gal activity, nuclear formation of SAHF, were increased significantly at 48?h in HG-treated RTECs. |
| Target gene: | OPTN |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | OPTN |
| Target gene experiment: | Western blot//SA-β-gal activity assay |
| Target gene description: | OPTN siRNA assay showed that silencing of OPTN gene significantly inhibited HG-induced mitophagosome formation and enhanced RTEC senescence . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: