External factors: | High glucose |
Aging type: | Accelerate |
Aging characteristic: |
Category: | Other |
Phenotype: | Aging |
Experiment: | SA-β-gal activity assay//Western blot//SAHF |
Description: | The expressions of senescence-associated markers, including P16, P21, cell membrane DcR2, cytoplasmic SA-β-Gal activity, nuclear formation of SAHF, were increased significantly at 48?h in HG-treated RTECs. |
Target gene: | OPTN |
R-EF-Target gene: | Downregulation |
Official symbol(s): | OPTN |
Target gene experiment: | Western blot//SA-β-gal activity assay |
Target gene description: | OPTN siRNA assay showed that silencing of OPTN gene significantly inhibited HG-induced mitophagosome formation and enhanced RTEC senescence . |
Regulatory pathway: | -- |
R-EF-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation: