Aging Overview

External factors

External factors: High glucose
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: RTEC
PMID: 29367621
Experiment: SA-β-gal activity assay//Western blot//SAHF
Description: The expressions of senescence-associated markers, including P16, P21, cell membrane DcR2, cytoplasmic SA-β-Gal activity, nuclear formation of SAHF, were increased significantly at 48?h in HG-treated RTECs.


Regulatory relationship

Target gene: OPTN
R-EF-Target gene: Downregulation
Official symbol(s): OPTN
Target gene experiment: Western blot//SA-β-gal activity assay
Target gene description: OPTN siRNA assay showed that silencing of OPTN gene significantly inhibited HG-induced mitophagosome formation and enhanced RTEC senescence .

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.