Aging Overview

External factors

External factors: 4 hydroxytamoxifen
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Breast cancer
Experimental category: L
Tissue type: --
Cell name: MCF-7
PMID: 21881167
Experiment: SA-β-gal activity assay
Description: The MCF7 cells adhered to the etched coverslips and essentially grew as colonies. After 6 days, the cells on the coverslips were processed for β-galactosidase staining as described [109]. Both doxorubicin (10-100 nM) and 4HT (50-1000 nM) induced senescence in MCF-7 cells in a dose-dependent fashion.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.