| External factors: | Ginsenoside Rb1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Cardiovascular disease |
| Experiment: | SA-β-gal activity assay |
| Description: | The results suggested that hyperlipidemia induced aortic endothelium senescence and that gRb1 could alleviate it.Results showed that gRb1, but not DMSO, has protective effects on ox-LDL-induced senescence and could alleviate the influence of ox-LDL on autophagy and SIRT1, while gRb1 did not influence senescence, autophagy and SIRT1 of young HUVECs. |
| Target gene: | SIRT1 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | SIRT1 |
| Target gene experiment: | Western blot |
| Target gene description: | The western blot results suggested that both low and high dose of gRb1 could alleviate the hyperlipidemia-induced reduction in SIRT1 levels and autophagy inhibition in the aortas. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: