| External factors: | Idebenone |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | When pretreated with 5 μ M idebenone, the increase in SA-β-Gal expression mediated by H2O2 was significantly ameliorated. |
| Target gene: | BAX//BCL-2 |
| R-EF-Target gene: | Downregulation//Upregulation |
| Official symbol(s): | BAX//BCL-2 |
| Target gene experiment: | qPCR |
| Target gene description: | After normalization to the control group, expression of BAX was 100% in control cells, 136 ± 28% in H2O2 treated cells, 115 ± 9% in cells treated with H2O2 and 5 μ M idebenone, and 103 ± 35% in cells treated with H2O2 and 7.5 μ M idebenone. Expression of Bcl-2 was 100% in control cells, 70 ± 20% in H2O2- treated cells, 83 ± 49% in cells treated with H2O2 and 5 μ M idebenone, and 115 ± 57% in cells treated with H2O2 and 7.5 μ M idebenone. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: