| External factors: | U0126 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Glaucoma |
| Experiment: | Western blot//Colony formation assay//SA-β-gal activity assay |
| Description: | Unlike rapamycin, U0126 completely eliminated cyclin D1. Both rapamycin and U0126 suppressed geroconverssion in p21- and p16-induced senescence, rendering cells that were able to resume proliferation and form colonies after arrest was released. Furthermore, treatment with U0126 alone resulted in senescent morphology. |
| Target gene: | CYCLIN D1 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | CYCLIN D1 |
| Target gene experiment: | Western blot |
| Target gene description: | Although rapamycin moderately decreased PD0332991-induced cyclin D1, U0126 completely eliminated it. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: