| External factors: | Hydrogen sulfide |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | Early passage cells seeded at PD = 44 treated with H2S donors demonstrated a reduction in the number of SA-β-Gal positive cells two passages later. |
| Target gene: | IL-8//SRSF2//HNRNPD |
| R-EF-Target gene: | Upregulation//Upregulation//Upregulation |
| Official symbol(s): | CXCL8//SRSF2//HNRNPD |
| Target gene experiment: | ELISA//TaqMan low density array |
| Target gene description: | Upon treatment with H2S donors, the only consistent change for all donors was an upregulation of IL8 expression, although this was not to levels comparable with younger passage cells.A significant increase of HNRNPD and SRSF2 were the only consistent changes in splicing factor expression produced by treatment with any H2S donor tested. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: