| External factors: | Mitochondrial ROS |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Mitochondrial Dysfunction |
| Experimental category: | HL |
| Tissue type: | Heart left ventricle |
| Cell name: | Human Cardiac Progenitor Cell |
| PMID: | 30629785 |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | Mitochondrial ROS was subsequently artificially increased while maintaining hypoxic conditions by inhibition of complex III with 100 μM antimycin A (AMA) for 9 days in hCPC-1%. However, a 220% increase in SA-β-gal+ positive cells was observed in hCPC-1% treated with AMA, suggesting mitochondrial ROS can directly drive hCPC senescence. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: