| External factors: | RTI |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Gynaecological Cancer |
| Experiment: | MTT assay//TRAP assay |
| Description: | Cell proliferation after 72 h of incubation was assessed by the MTT assay. Both the cell lines demonstrated reduced proliferation with increasing concentrations of RTI. |
| Target gene: | P53//P21 |
| R-EF-Target gene: | Upregulation//Upregulation |
| Official symbol(s): | P53//P21 |
| Target gene experiment: | RT-PCR |
| Target gene description: | In HEC-1 cells, the expression of TP53 increased with ddI (P< 0.001).The expression of p21 increased with ddI (P< 0.001). |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: