| External factors: | Cardiac glycoside |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | The number of SA-β-Gal positive cells increased after the treatment of all cardiac glycosides for 72 h, significantly indicating the cardiac glycoside-induced senescence in HeLa cells. |
| Regulatory pathway: | Rho-Rho |
| R-EF-Pathway: | -- |
| Official symbol(s): | rhodopsin |
| Pathway experiment: | Cell morphological analysis |
| Pathway description: | The measurements demonstrated that cardiac glycosides increased the cell areas in HeLa cells comparing to the control group. Pretreatment of Rock inhibitor, Y-27632, significantly reduced the increased cell area induced by cardiac glycosides. |
Annotation: