| External factors: | Doxorubicin |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Nijmegen Breakage Syndrome |
| Experiment: | SA-β-gal activity assay |
| Description: | We observed a time-dependent increase in the number of SA-β-Gal positive cells in L5 and S4, but not in S3R cell line. |
| Regulatory pathway: | p16-pRb//p53-p21 |
| R-EF-Pathway: | Downregulation//Activation |
| Pathway experiment: | Western blot |
| Pathway description: | We did not observe any changes in the level of this protein in the S3R and S4 cell lines, however, a time dependent decrease in the level of p16 was observed in the L5 cell line.In the L5 and S4 cells stronger activation of the p53/ p21 pathway correlated with an increase in SA-β-Gal activity. |
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