| External factors: | N-Acetylcysteine |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | Flow cytometry//PCR//SA-β-gal activity assay//Telomerase activity assay |
| Description: | Incubation with N-acetylcysteine starting from populationdoubling 26 prevented the increase in ROS formation and the reduction of intact mitochondrial DNA. Furthermore, the reduction of nuclear TERT activity was blocked by N-acetylcysteine. Moreover, N-acetylcysteine prevented the reduction in overall TERT activity during further passaging and delayed the onset of replicative senescence. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: