| External factors: | Pioglitazone and Melatonin |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | We investigated the inhibitory effects of pioglitazone and melatonin on MSC senescence induced by IS. The combination therapy of pioglitazone and melatonin significantly reduced IS-induced increase of SA-β-gal activity. |
| Target gene: | P21 |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | P21 |
| Target gene experiment: | Western blot |
| Target gene description: | Pioglitazone?and?melatonin?ameliorated?the?IS‐induced?reduction?in?SMP30?expression?and?inhibited?the?increase in p21. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: