| External factors: | Resveratrol |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Renal?injury |
| Experiment: | Immunostaining//Western blot |
| Description: | The area of tubulointerstitial fibrosis was decreased in the RSV group compared to that in the Cont group.There was no difference in the expression of BAX between the two groups, while that of BCL-2 was increased in the RSV group. |
| Target gene: | HO-1//NQO-1 |
| R-EF-Target gene: | Upregulation//Upregulation |
| Official symbol(s): | HMOX1//NQO1 |
| Target gene experiment: | Western blot |
| Target gene description: | HO-1 expression in aging kidney was decreased, and inversely increased in the RSV group .The expression of NQO-1 was significantly increased in the RSV group compared to that in the Cont group. |
| Regulatory pathway: | Nrf2//SIRT1-AMPK//PPARα |
| R-EF-Pathway: | Upregulation//Upregulation//Upregulation |
| Official symbol(s): | NFE2L2//SIRT1-PRKAA1//PPARA |
| Pathway experiment: | Western blot |
| Pathway description: | Nrf2 levels in total protein were dramatically increased in the RSV group (Cont 1 ± 0.04-fold vs. RSV 1.55 ± 0.09-fold, P<0.01;).Western blot analysis showed that SIRT1 protein levels were considerably increased in the RSV group compared to those in the Cont group.The phospho-Thr172/total-AMPK protein expression ratio was markedly increased in the RSV group compared to that in the Cont group .Also, PPARα levels were statistically increased along with PGC-1α and ERRα expressions ,which were recovered in the RSV group compared to that in the Cont group. |
Annotation: