| External factors: | Gomisin A |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | The aged HDF cells (PD61) showed markedly higher levels of SA-β-gal activity than the middle passage cells,while gomisin A significantly reduced aging induced SA-β-gal activity. |
| Regulatory pathway: | MAPK-NF-κB |
| R-EF-Pathway: | Downregulation |
| Official symbol(s): | MAPK |
| Pathway experiment: | Western blot |
| Pathway description: | The SIPS-HDF cells activated MAPK signaling including p-ERK, p-p38, and p-JNK, but gomisin A inhibited the SIPS-induced MAPKs. Furthermore, gomisin A blocked the NF-κB translocation from the cytosol to the nucleus. |
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