| External factors: | Cyclin-dependent kinase inhibitors |
| Aging type: | Accelerate |
| Aging characteristic: | Others |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | Cell proliferation assay//Cell morphological analysis//SA-β-gal activity assay//PCR |
| Description: | As judged by cell proliferation assays, cells expressing the Cdk inhibitors had a significantly lower rate of division than cells transduced with the empty vector.?As well as being growth arrested, the majority of the infected cells were enlarged and flattened in appearance (data not shown).The cells also had increased expression of the mRNA for PAI-1,which is involved in regulating the turnover of extracellular matrix proteins.Ectopic expression of any of the Cdk inhibitors was sufficient to induce positive staining for SA-β-gal activity. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: