AgingReG
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Aging Overview

External factors

External factors: Ultraviolet radiation
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: HL
Tissue type: --
Cell name: HDF
PMID: 30118525
Experiment: SA-β-gal activity assay
Description: When cells were exposed to UVA (7.5 J/cm2) or UVB (0.25 J/cm2) for 24 h, S HDFs showed an increased number of SA-β-gal positive cells as compared to control-treated cells, whereas NS HDFs showed negative staining for SA-β-gal activity.

Regulatory relationship

Regulatory pathway: TLR4-ERK
R-EF-Pathway: --
Official symbol(s): TLR4-MAPK1
Pathway experiment: Mitochondrial flux analysis
Pathway description: Furthermore, ERK or TLR4 inhibitor-treated senescent HDFs had strikingly decreased OCR than control-treated cells, suggesting that TLR4-ERK signaling pathways can lead to control of mitochondrial metabolic profilings in senescent HDFs.

Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.


Pathway view

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonEndogenous TLR signalingIKK complex recruitment mediated by RIP1IL-1_signaling(through_IKK-NFkB_cascade)(canonical) ( IL-1 signaling pathway (through NF-kappaB) ) IRAK4 deficiency (TLR2/4)Ligand-dependent caspase activationMyD88-independent TLR3/TLR4 cascadeMyD88 deficiency (TLR2/4)MyD88:Mal cascade initiated on plasma membraneToll-like receptor signaling pathway (p38 cascade) ( Toll-like receptor signaling pathway (p38 cascade) ) Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) ) Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) ) Toll-like receptor signaling pathway (through JNK cascade)(Canonical) ( Toll-like receptor signaling pathway (through JNK cascade) ) Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK, TAK1 and IKK-NF-kappaB cascade)(Canonical) ( Toll-like receptor signaling pathway (trough NF-kappaB) ) Toll Like Receptor 4 (TLR4) CascadeToll receptor signaling pathwayTRAF6 mediated induction of TAK1 complexTRIF-mediated programmed cell deathPhagosomeToll-like receptor signaling pathwayPathogenic Escherichia coli infectionLeishmaniasisChagas diseaseMalariaToxoplasmosisAmoebiasisHs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017Hs_Regulation_of_toll-like_receptor_signaling_pathway_WP1449_81172Hs_Pathogenic_Escherichia_coli_infection_WP2272_78594Hs_Toll-like_Receptor_Signaling_WP3858_89945
Activation of the AP-1 family of transcription factorsAdvanced glycosylation endproduct receptor signalingAKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) ALK1 signaling eventsAlpha6Beta4IntegrinAlzheimer disease-amyloid secretase pathwayAngiogenesisAngiopoietin receptor Tie2-mediated signalingAngiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestinApoptosis signaling pathwayArf6 downstream pathwayATF-2 transcription factor networkB cell activationBCRBCR signaling pathwayBMP receptor signalingCDC42 signaling eventsCellular roles of Anthrax toxinCeramide signaling pathwayClass IB PI3K non-lipid kinase eventsCREB phosphorylation through the activation of RasCXCR3-mediated signaling eventsCytokine gene transcriptionDownstream signaling in naïve CD8+ T cellsDrosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) EGF receptor signaling pathwayEGFR1EndothelinsEPHB forward signalingErbB1 downstream signalingErbB2/ErbB3 signaling eventsErbB4 signaling eventsERK cascade ( B cell receptor signaling ) ERK cascade ( CD4 T cell receptor signaling (ERK cascade) ) ERK cascade ( CD4 T cell receptor signaling ) ERK cascade ( EGF signaling pathway Diagram ) ERK cascade ( FGF signaling pathway ) ERK cascade ( FGF8 signaling (Mouse) ) ERK cascade ( FGF8 signaling (Xenopus) ) ERK cascade ( GPCR Adenosine A2A receptor signaling pathway ) ERK cascade ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) ERK cascade ( GPCR signaling (G alpha q) ) ERK cascade ( GPCR signaling (G alpha s, Epac and ERK) ) ERK cascade ( HGF signaling pathway ) ERK cascade ( IGF1 signaling pathway ) ERK cascade ( Insulin receptor signaling (D. melanogaster) ) ERK cascade ( Insulin receptor signaling (Mammal) ) ERK cascade ( JAK-STAT pathway and regulation pathway Diagram ) ERK cascade ( NGF signaling pathway ) ERK cascade ( VEGF signaling pathway ) ERK/MAPK targetsERKs are inactivatedFc-epsilon receptor I signaling in mast cellsFc Epsilon Receptor I Signaling in Mast CellsFCERI mediated MAPK activationFGF signaling pathwayFGF signaling pathwayFSHGastrin-CREB signalling pathway via PKC and MAPKGlucocorticoid receptor regulatory networkGMCSF-mediated signaling eventsGolgi Cisternae Pericentriolar Stack ReorganizationGrowth hormone receptor signalingIDIFN-gamma pathwayIL-7IL1IL2-mediated signaling eventsIL2IL3IL4IL5IL6IL9Inflammation mediated by chemokine and cytokine signaling pathwayInsulin SignallingInsulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascadeIntegrins in angiogenesisInterferon-gamma signaling pathwayInterleukin signaling pathwayIntracellular Signalling Through Adenosine Receptor A2a and AdenosineIntracellular Signalling Through Adenosine Receptor A2b and AdenosineJNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) KitReceptorLeptinMAP2K and MAPK activationMAPK1 (ERK2) activationmTOR signaling pathwayNCAM signaling for neurite out-growthNegative feedback regulation of MAPK pathwayNegative regulation of (nuclear import of R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) Negative regulation of FGFR1 signalingNegative regulation of FGFR2 signalingNegative regulation of FGFR3 signalingNegative regulation of FGFR4 signalingNegative regulation of MAPK pathwayNetrin-mediated signaling eventsNeurotrophic factor-mediated Trk receptor signalingNongenotropic Androgen signalingNotchOncogene Induced SenescenceOsteopontin-mediated eventsOxidative Stress Induced SenescenceParkinson diseasePDGF signaling pathwayPDGFR-beta signaling pathwayPI5P, PP2A and IER3 Regulate PI3K/AKT SignalingPositive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) Presenilin action in Notch and Wnt signalingProlactinRAF-independent MAPK1/3 activationRAF/MAP kinase cascadeRANKLRas PathwayRas signaling in the CD4+ TCR pathwayRecycling pathway of L1Regulation of actin dynamics for phagocytic cup formationRegulation of cytoplasmic and nuclear SMAD2/3 signalingRegulation of HSF1-mediated heat shock responseRegulation of TelomeraseRetinoic acid receptors-mediated signalingRHO GTPases Activate WASPs and WAVEsRSK activationS1P1 pathwayS1P2 pathwayS1P3 pathwayS1P4 pathwaySenescence-Associated Secretory Phenotype (SASP)Signal attenuationSignal transduction by L1Signaling events mediated by focal adhesion kinaseSignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)Signaling events mediated by PRLSignaling events mediated by VEGFR1 and VEGFR2Signaling events regulated by Ret tyrosine kinaseSpry regulation of FGF signalingSyndecan-1-mediated signaling eventsSyndecan-2-mediated signaling eventsT cell activationTCRTGF-beta signaling pathwayTGF_beta_ReceptorThrombin signalling through proteinase activated receptors (PARs)TNFalphaTRAIL signaling pathwayTrk receptor signaling mediated by the MAPK pathwayTSHTSLPTWEAKVEGF signaling pathway ( VEGF signaling pathway ) VEGF signaling pathwayVEGFR1 specific signalsVEGFR3 signaling in lymphatic endotheliumWntERK cascade ( Integrin signaling pathway ) ERK cascade ( PDGF signaling pathway ) untitledMAPK signaling pathwayErbB signaling pathwayMAPK signaling pathway - flyChemokine signaling pathwayOocyte meiosismTOR signaling pathwayVascular smooth muscle contractionDorso-ventral axis formationTGF-beta signaling pathwayAxon guidanceVEGF signaling pathwayFocal adhesionAdherens junctionGap junctionToll-like receptor signaling pathwayNOD-like receptor signaling pathwayNatural killer cell mediated cytotoxicityT cell receptor signaling pathwayB cell receptor signaling pathwayFc epsilon RI signaling pathwayFc gamma R-mediated phagocytosisLong-term potentiationNeurotrophin signaling pathwayLong-term depressionRegulation of actin cytoskeletonInsulin signaling pathwayGnRH signaling pathwayProgesterone-mediated oocyte maturationMelanogenesisType II diabetes mellitusAldosterone-regulated sodium reabsorptionAlzheimer's diseasePrion diseasesShigellosisLeishmaniasisChagas diseaseToxoplasmosisHepatitis CPathways in cancerColorectal cancerRenal cell carcinomaPancreatic cancerEndometrial cancerGliomaProstate cancerThyroid cancerMelanomaBladder cancerChronic myeloid leukemiaAcute myeloid leukemiaNon-small cell lung cancerHs_BDNF-TrkB_Signaling_WP3676_89741Hs_ErbB_Signaling_Pathway_WP673_91869Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278Hs_Endothelin_Pathways_WP2197_74852Hs_Association_Between_Physico-Chemical_Features_and_Toxicity_Associated_Pathways_WP3680_90113Hs_Leptin_signaling_pathway_WP2034_89856Hs_Wnt_Signaling_Pathway_Netpath_WP363_78571Hs_Angiogenesis_WP1539_88983Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668Hs_TNF_related_weak_inducer_of_apoptosis_(TWEAK)_Signaling_Pathway_WP2036_89910Hs_Heart_Development_WP1591_90186Hs_Bladder_Cancer_WP2828_89143Hs_Spinal_Cord_Injury_WP2431_87678Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687Hs_IL17_signaling_pathway_WP2112_89838Hs_Estrogen_signaling_pathway_WP712_78491Hs_MFAP5-mediated_ovarian_cancer_cell_motility_and_invasiveness_WP3301_87836Hs_Kit_receptor_signaling_pathway_WP304_78799Hs_ERK_Pathway_in_Huntington's_Disease_WP3853_89748Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010Hs_Type_II_diabetes_mellitus_WP1584_81779Hs_IL-5_Signaling_Pathway_WP127_78498Hs_G1_to_S_cell_cycle_control_WP45_80001Hs_IL-2_Signaling_Pathway_WP49_91243Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101Hs_TGF-beta_Signaling_Pathway_WP366_90028Hs_IL-6_signaling_pathway_WP364_89832Hs_Prolactin_Signaling_Pathway_WP2037_90015Hs_IL-4_Signaling_Pathway_WP395_89828Hs_EGF-EGFR_Signaling_Pathway_WP437_79266Hs_Nanoparticle-mediated_activation_of_receptor_signaling_WP2643_87898Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937Hs_Alpha_6_Beta_4_signaling_pathway_WP244_85199Hs_IL-3_Signaling_Pathway_WP286_78583Hs_IL-7_Signaling_Pathway_WP205_89854Hs_Follicle_Stimulating_Hormone_(FSH)_signaling_pathway_WP2035_86080Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900Hs_IL-9_Signaling_Pathway_WP22_79264
Expression of gene(s)
Cell line (ENCODE) Primary cell (ENCODE) Normal tissue (GTEx) Cell line (CCLE)