| External factors: | MIF |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | CCK-8 assay//SA-β-gal activity assay//RT?qPCR |
| Description: | MIF treatment in cells exposed to radiation increased cellular proliferation, decreased the expression levels of the senescence?associated genes Cdkn1a and Cdkn2c , recovered the impaired relative telomere length and activity ,and reduced the percentage of SA?β?gal?positive cells. |
| Target gene: | MIR-34A |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | MIR-34A |
| Target gene experiment: | qRT-PCR |
| Target gene description: | Exogenous MIF significantly decreased the expression of miR?34a induced by radiation. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: