External factors: | Palmitic acid |
Aging type: | Accelerate |
Aging characteristic: |
Category: | Chemical compounds |
Phenotype: | Aging |
Experiment: | qPCR//SA-β-gal activity assay//Western blot |
Description: | PA treatment led to a reduction of SMARCD1 expression in HepG2 cell, and induced cellular senescence in HepG2 cells, demonstrated by an increased number of cells with high levels of SA-β-Gal activity, p16/p21 expression, p-p38 expression, and γH2AX expression in the PA-treated HepG2 cells. |
Regulatory pathway: | -- |
R-EF-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation: