| External factors: | Paclitaxel |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis |
| Description: | Treatment with paclitaxel, sirolimus, and everolimus significantly induced a senescent phenotype as judged by SA-βgal and an enlarged, flattened cell morphological appearance at 10 days. |
| Target gene: | PAI-1//ENOS//SIRT1 |
| R-EF-Target gene: | Upregulation//Downregulation//Downregulation |
| Official symbol(s): | SERPINE1//ENOS//SIRT1 |
| Target gene experiment: | Western blot |
| Target gene description: | In parallel with SA-βgal, expression of PAI-1 was increased by treatment with paclitaxel, sirolimus, and everolimus .Paclitaxel, sirolimus, and everolimus decreased the expression of eNOS and Sirt1. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: