| External factors: | Tea polyphenols |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Flow cytometry//Southern blot |
| Description: | We found that the percentage of SA-β-Gal-positive cells was significantly lower in the TP group than in the HG group . The rate of G1 phase was lower in the TP group than in the HG group. Further, the telomere length of HGMCs in the TP group was also significantly longer than that in the HG group . |
| Regulatory pathway: | Akt-p53-p21//miR-126 |
| R-EF-Pathway: | Activation//-- |
| Official symbol(s): | CDKN1A-TP53//MIR126 |
| Pathway experiment: | Western blot//qRT-PCR |
| Pathway description: | With regard to the effect of TP, the expression of p-Akt was significantly higher and the expression of p53, p21 and Rb was significantly lower in the TP group than in the HG group.MiR-126 expression in the HG group was significantly lower than that in the NG group. In the TP group, the expression of miR-126 was significantly higher than that in the HG group (P < 0.05). |
Annotation: