Aging Overview

External factors

External factors: Tea polyphenols
Aging type: Prevent
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: HMSC
PMID: 31089945
Experiment: SA-β-gal activity assay//Flow cytometry//Southern blot
Description: We found that the percentage of SA-β-Gal-positive cells was significantly lower in the TP group than in the HG group . The rate of G1 phase was lower in the TP group than in the HG group. Further, the telomere length of HGMCs in the TP group was also significantly longer than that in the HG group .


Regulatory relationship

Regulatory pathway: Akt-p53-p21//miR-126
R-EF-Pathway: Activation//--
Official symbol(s): CDKN1A-TP53//MIR126
Pathway experiment: Western blot//qRT-PCR
Pathway description: With regard to the effect of TP, the expression of p-Akt was significantly higher and the expression of p53, p21 and Rb was significantly lower in the TP group than in the HG group.MiR-126 expression in the HG group was significantly lower than that in the NG group. In the TP group, the expression of miR-126 was significantly higher than that in the HG group (P < 0.05).


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view