| External factors: | DmHsp22 |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | We found significant lower level of β-galactosidase expression in DmHsp22-expressing cells .Control cells entered senescence at 45 PD, as marked by their morphology and slow growth, the DmHsp22-expressing cells showed younger morphology and continued dividing until~5 PD . |
| Regulatory pathway: | p53 |
| R-EF-Pathway: | Downregulation |
| Official symbol(s): | TP53 |
| Pathway experiment: | Western blot//Immunostaining |
| Pathway description: | The intensity of nuclear p53 staining in DmHsp22-expressing cells was lower as compared with the control cells. Furthermore, inDmHsp22-expressing U2OS cells, we found that there was a significant decrease in DNA damage-induced activation of p53 pathway. |
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