| External factors: | NE |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Cystic Fibrosis |
| Experiment: | Western blot |
| Description: | These results suggest that NE may activate airway epithelial senescence in CF via p16-mediated inhibition of CDK4 and failure of phospho-Rb-triggered DNA synthesis.NE treatment injured the epithelial monolayer in a dose-dependent manner. |
| Target gene: | P16//CDK4 |
| R-EF-Target gene: | Upregulation//Downregulation |
| Official symbol(s): | P16//CDK4 |
| Target gene experiment: | Western blot//Kinase assay |
| Target gene description: | Western analyses demonstrated a significant increase in p16 protein expression in response to NE treatment；NE treatment significantly decreased phosphorylation of Rb, the substrate for CDK4 activity . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: