| External factors: | Ang II |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Telomerase activity assay |
| Description: | AngII was able to accelerate EPCs senescence as shown by the increased percentage of positive SA-β-gal staining cells and the decreased telomerase activity concomitantly with the increase in the mRNA expression of NADPH oxidase gp91phoxsubunit and intracellular ROS production shown by fluorescent dichlorofluorescein. |
| Target gene: | KLOTHO |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | KLOTHO |
| Target gene experiment: | Western blot//PCR |
| Target gene description: | AngII was able to accelerate EPCs senescence as shown by the decrease in the expression of both Klotho mRNA and secreted Klotho protein. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: