| External factors: | Hinokitiol |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Cervical cancer |
| Experiment: | SA-β-gal activity assay |
| Description: | SA-β-gal assay results showed that ?hinokitiol treatment obviously increased β-galactosidase activity as ?compared with control. |
| Target gene: | CYCLIN D1//CYCLIN E |
| R-EF-Target gene: | Downregulation//Downregulation |
| Official symbol(s): | CYCLIN D1//CYCLIN E |
| Target gene experiment: | Western blot |
| Target gene description: | Results of western ?blotting showed that the protein levels of cyclin D1 and cyclin E ?were significantly downregulated in cells treated with hinokitiol in ?a dose-dependent manner. |
| Regulatory pathway: | p53-p21 |
| R-EF-Pathway: | Activation |
| Official symbol(s): | TP53-CDKN1A |
| Pathway experiment: | Western blot |
| Pathway description: | An increase in both p21 and p53 level was ?observed in hinokitiol-treated cells. |
Annotation: