Aging Overview

External factors

External factors: PD-0332991
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: HL
Tissue type: --
Cell name: MCF-7,LCC9
PMID: 21367843
Experiment: SA-β-gal activity assay
Description: Interestingly, while PD-0332991 treatment resulted in a significant fraction of cells staining positively for senescence-associated β-galactosidase (in agreement with other studies), endocrine therapy did not mediate this response.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.